Cardiac adverse effects of domperidone in adult patients: a systematic review. Rosario, Argentina. Correspondencia a :. Background: Domperidone is widely prescribed in patients with gastrointestinal disorders but some cardiac adverse effects have been recently reported. Aim : To evaluate the risk of QT prolongation, ventricular arrhythmias and sudden cardiac death associated with the use of oral domperidone in adults without cancer.
The search strategy consisted of combining free and indexed text words without any date or language restriction. Results : Three case-control studies met the inclusion criteria; none of them evaluated QT interval prolongation. The odds ratios for these events in these studies were 4. Conclusions: Heterogeneity between selected studies did not allow the computation of a summary measure. Diversas agencias sanitarias han advertido acerca del uso de domperidona en cualquiera de sus presentaciones Criterios de elegibilidad.
Se recuperaron los textos completos de los 23 remanentes. Figura 1. Los requisitos restantes fueron respondidos satisfactoriamente en los tres estudios. Tabla 1. Resultados de los estudios individuales. Tabla 2. De Bruin et al, Johannes et al, Van Noord et al, Sugerencias para estudios futuros. Nora Beatriz Quaglia. Referencias 1. Sharkey K, Wallace J.
Cisapride plasma levels and corrected QT interval in infants undergoing routine polysomnography. J Pediatr Gastroenterol Nutr ; Cardiac arrhythmias during cytotoxic chemotherapy: role of domperidone. Hum Toxicol ; 4: QT interval prolongation associated with the oral use of domperidone in an infant.
Pediatr Cardiol ; Non-cardiac QTc-prolonging drugs and risk of sudden cardiac death. Eur Heart J ; Gastroenterology ; 5 Supplement 1 , S Health Canada.
