Age-related impairments in protein quality control i. Our overall research goal is to determine the protein quality control mechanisms that become compromised with aging thereby identifying novel targets for therapy.
Deciphering the intracellular and cross-tissue pathways responsible for the exercise- and calorie restriction-mediated improvements of quality control processes is also of major interest. We conduct functional studies combining unbiased approaches e. Full list of published work in NCBI. Google Scholar. Loss of FoxOs in muscle increases strength and mitochondrial function during aging. J Cachexia Sarcopenia Muscle. J Appl Physiol J Am Heart Assoc. Front Physiol. Dec 31;23 1. ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue.
Cell Rep. Skeletal muscle type-specific mitochondrial adaptation to high-fat diet relies on differential autophagy modulation. Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle. J Clin Invest. Regular exercise stimulates endothelium autophagy via IL-1 signaling in ApoE deficient mice. Guidelines for the use and interpretation of assays for monitoring autophagy 4th edition 1. The effects of diet composition and chronic obesity on muscle growth and function.
ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle. Cervical vagal nerve stimulation impairs glucose tolerance and suppresses insulin release in conscious rats. Physiol Rep. Mol Ther. Circ Res. Vitor Lira. You are here Home » People » Vitor Lira. Associate Professor. Human Physiology.
Muscle biology, autophagy, protein synthesis, exercise physiology, substrate metabolism. PhD in Exercise Physiology. University of Florida; Postdoc: University of Virginia.
